Treatments

There are now many treatments available for Osteoporosis. All medications have potential side effects whether they are for Osteoporosis or any another condition. When dealing with Osteoporosis, the risk of fracture usually far outweighs the risk of possible side effects. Please speak to your doctor and/or an Osteoporosis/bone specialist.

Download this PDF on the possible side affects from osteoporosis medications.

For more detailed information on treatments please contact the Irish Medicines board at:

Tel: 01 676 4971 Email: imb@imb.ie or www.imb.ie

Which treatment a person is put on is usually based on the following:

  • Risk of fracture or re-fracture
  • Cause/s of their Osteoporosis
  • Their age
  • DXA scan results of their spine and hips
  • Medical history

Taking the recommended daily amount of Calcium, Vitamin D and weight bearing exercise are essential for the prevention of Osteopenia/Osteoporosis and also the treatment for patients with Osteopenia/Osteoporosis along with the appropriate medication.

Calcium and Vitamin D supplements
They help provide building blocks for healthy bone production. The brand names of some are the following:

  • Calcichew D3 Forte
  • Osteofos D 3 forte
  • Caltrate Plus

HRT - Estrogen/Hormone Therapy
There are multiple brands available. They are oestrogen replacement for women going through the menopause and help to maintain bone density and reduce fracture rates for the duration they are on the treatment. Estrogen therapy and estrogen with progesterone hormone therapy are approved for the prevention of Osteoporosis in postmenopausal women provided there are no contraindications. They are usually recommended for post menopausal symptoms to help improve the person's quality of life. They may also be prescribed for premenopausal women who have amenorrhea and low levels of oestrogen.

Strontium Ranelate
It has a dual action, it prevents bone loss and increases bone mineral density through the formation of new normal strong bone.

The brand name is Protelos ; one sachet with water daily

 

Selective Estrogen Receptor Modulators (SERMs)

Bazedoxifine Acetate

1)      The brand name is Conbriza. SERMs work in a similar way to oestrogen on bone by preventing bone loss in postmenopausal women who do not have hot flushes and also provided there are no other contraindications. 

 

2)      The brand name is Evista®. SERMs work in a similar way to oestrogen on bone by preventing bone loss in postmenopausal women who do not have hot flushes and also provided there are no other contraindications. 

 

Monoclonal Antibody

Denosumab, the brand name is Prolia. It is a Monoclonal antibody which binds to RANK Ligand, inhibiting the maturation of osteoclasts, thus protecting the bone from degradation. Bisphosphonates which are also known as Antiresorptive medications


These are non hormonal drugs which help maintain bone density and prevent further bone loss.

The following are a list of the brands of bisphosphonates:

  • Boniva® Can be given in tablet monthly
  • Boniva® Can be given by IV four times a year
  • Fosamax® - Can be given in tablet which is taken once weekly
  • Fosamax® plus D - Fosamax is a tablet which is taken weekly
  • Fosavance 5600 tablet which is taken once weekly
  • Actonel® - This is a tablet which can taken daily /weekly
  • Actonel® with Calcium. Actonel Combi- Actonel is a tablet is taken weekly and Ca is taken the other 6 days
  • Actonel plus Ca & D , Actonel tablet is taken once weekly and a sachet the other 6 days
  • Aclasta ® is a once-a-year IV Osteoporosis treatment. 

Parathyroid Hormone -(PTH)
Bone forming agents that stimulates the formation of new bone.

  • Forsteo = (1-34) It is given as a daily injection for 24 months
  • Preotact = (1-84) It is given as a daily injection for 18 months 

Kyphoplasty
This is a surgical treatment which involves a balloon being placed within the fractured vertebrae, followed by a “bone cement” being injected into the balloon. 

Vertebroplasty
This is a non surgical treatment which involves a needle with “bone cement” in it, inserted through the skin into the fractured body of the vertebrae.